Antitubercular drugs induced hepatic oxidative stress and ultrastructural changes in rats

Antitubercular drugs induced hepatic oxidative stress and ultrastructural changes in rats

Methods The rats were divided into three groups (n=6 per group), group I served as a control, group II received orally combination of isoniazid (15mg/kg body weight), rifampicin (20mg/kg body weight) and pyrazinamide (35mg/kg body weight) daily for 45 days and group III received simultaneously Silymarin (50mg/kg body weight) and combination of anti-TB drugs at the above mentioned dosages for 45...

Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

Prior exercise training attenuated Doxorubicin-induced hepatic oxidative stress in Wistar rats: Age-related differences

Introduction: Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but pretreatment effect of regular Aerobic exercise in restrain of hepatotoxicity induced by doxorubicin is not clear. The aim of this study was to investigate the pretreatment effect of regular aerobic exercise on hepatic oxidative stress induced with doxorubicin of Wistar rats in differ...

Evaluation of the effect of taurine on cisplatin-induced hepatic injury and oxidative stress in male rats

Introduction: The principal dose-limiting factor in the use of cisplatin as an antineoplastic drug is its hepatic toxicity. This study was designed to investigate the protective role of taurine against cisplatin-induced hepatic injury. Methods: Male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): cisplatin-treated group (10 mg/kg ip) (3): g...

Retracted: Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats